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The split-dose regimen has been shown in multiple studies to be better than the day-before regimen for morning colonoscopies. Split dosing is associated with increased patient’s acceptance, tolerability and compliance. It leads to better bowel preparation. Almost all bowel preparation agent or purgative can be split-dosed. This table shows the different bowel prep agents, main ingredients, the evening before the colonoscopy dose, the morning of the colonoscopy dose, and the total volume.
| Agent | Ingredients | Evening Volume | Morning Volume | Total Volume |
|---|---|---|---|---|
| Plenvu (Salix) | PEG 3350 ES | 0.5L solution 16.9oz | 0.5L solution 16.9oz | 1L 33.8oz |
| Colyte (Alaven) | PEG 3350 ES | 2L solution 67.6oz | 2L solution 67.6oz | 4L 135oz |
| GoLYTELY (Braintree) | PEG 3350 ES | 2L solution 67.6oz | 2L solution 67.6oz | 4L 135oz |
| NuLYTELY (Braintree) | PEG 3350 ES | 2L solution 67.6oz | 2L solution 67.6oz | 4L 135oz |
| TriLyte (Alaven) | PEG 3350 ES | 2L solution 67.6oz | 2L solution 67.6oz | 4L 135oz |
| HalfLytely (Braintree) | PEG 3350 ES, Bisacodyl | One 5mg Bisacodyl with sip of water 2L solution | None | 67.6oz |
| MoviPrep (Salix) | PEG, Na sulfate, NaCL, KCL, Na ascorbate, ascorbic acid | 33.8oz (MoviPrep powder + 1L water) 16oz water 49.8oz | 33.8oz (MoviPrep powder + 1L water) 16oz water 49.8oz | 99.6oz |
| SUPREP (Braintree) | Na sulfate, K sulfate, Mg sulfate | 16oz (6oz Suprep powder + 10oz water) 32oz water 48oz | 16oz (6oz Suprep powder + 10oz water) 32oz water 48oz | 96oz |
| OsmoPrep (Salix) | Na phosphate tablets | 20 tablets 40oz water 40oz water | 12 tabs 24oz water 24oz water | 64oz water |
| Visicol (Salix) | Na phosphate tablets | 20 tablets 56 oz water 56 oz | 20 tablets 56 oz water 56 oz | 112oz water |
| Prepopik (Ferring) | Na Picosulfate, Mg oxide, citric acid | 5oz Prepopik solution 40oz water 45oz | 5oz Prepopik solution 24oz water 29 oz | 74oz |
| CLENPIQ (Ferring) | Na Picosulfate, Mg oxide, citric acid | 5.4oz CLENPIQ solution 5.4oz | 5.4oz CLENPIQ solution 5.4 oz | 10.8oz |
| Miralax (Bayer) with Gatorade | PEG | 119g PEG 3350 powder 32oz Gatorade 32oz | 119g PEG 3350 powder 32oz Gatorade 32oz | 64oz |
How to do the split dosing
- Do not consume the entire bowel cleansing agent at once or on the same day.
- Take half the total dose of the bowel cleansing agent the evening before your colonoscopy. This is usually between 5:00-7:00 PM.
- Continue to consume clear liquid diet after the first dose of the bowel cleansing agent.
- Take the second half of your bowel cleansing agent on the day of your colonoscopy, about 4-5 hours before your scheduled colonoscopy.
- Do not consume anything at least 2 hours before your colonoscopy.
Video on how to use bowel cleansing agents
Suggested Reading
How to use your bowel cleansing agents for colonoscopy.
Medications and foods to stop before colonoscopy.
How to tell if your bowel is clean prior to colonoscopy.
